PLASMA BUPIVACAINE CONCENTRATIONS DURING COMBINED REGIONAL AND GENERAL ANAESTHESIA FOR RESECTION AND RECONSTRUCTION OF HEAD AND NECK CARCINOMATA
- 1 May 1984
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 56 (5) , 485-492
- https://doi.org/10.1093/bja/56.5.485
Abstract
Venous plasma bupivacaine concentrations were measured in patients undergoing resection and reconstruction surgery for intra-oral malignancy. Fifth cranial nerve and cervical plexus blocks were performed using 0.5% bupivacaine. Total dosage was higher than recommended by UK manufacturers. Mean peak venous plasma concentrations were higher than previously recorded. A significant difference was found in the peak concentrations when adrenaline [epinephrine] was included. The significance of these results in relation to systemic toxicity and recommended dosage is discussed.This publication has 1 reference indexed in Scilit:
- Gas-liquid chromatographic determination of bupivacaine and lidocaine in plasma.Clinical Chemistry, 1978