INTERSTITIAL FLUID COLLOID OSMOTIC AND HYDROSTATIC PRESSURES IN SUBCUTANEOUS TISSUE OF PATIENTS WITH NEPHROTIC SYNDROME

  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (2) , 139-146
Abstract
Colloid osmotic pressure in plasma (IIp) and in interstitial fluid from subcutaneous tissue (IIi) was measured in 13 patients with nephrotic syndrome and in 20 healthy volunteers. Interstitial fluid was sampled by nylon wicks, and interstitial fluid pressure was measured by the wick-in-needle technique. In persons with normal plasma proteins a mean IIp f 26.9 mmHg, a mean IIi of 15.8 mmHg on the thorax and a mean IIi of 11.1 mmHg on the lower leg were found. A fall of IIp from normal values to 16.5 mmHg caused a fall in IIi of .apprx. 8 mmHg on the thorax and .apprx. 7 mmHg on the leg without edema formation. In patients with IIp from 16.0 mmHg to 8.0 mmHg, IIi did not change very much, and was .apprx. 5.5 mmHg on the thorax and 2.6 mmHg on the leg. Apparently, reduction of IIi plays an important role as an edema preventing factor in patients with hypoproteinemia.