Polarographic and Spectrophotometric Determination of Nimodipine in Tablets

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Abstract
Nimodipine is a calcium-channel blocker primarily used for its cerebral vasodilatory effect. The compound produces a d.p. polarographic peak due to the reduction of the nitro to the hydroxylamine group in a four electron process. The electroactivity of the nitro group was used in order to develop a new polarographic method. Furthermore, the UV absorption band at 360 nm of nimodipine was used as a comparative UV spectrophotometric method. The polarographic assay was applied to commercial samples [tablets] of two different pharmaceutical laboratories. Adequate precision and accuracy were obtained, thefore, the developed method is strongly recommended for uniformity content studies and stability test of nimodipine in routine analysis.