Microbial Oxidation in Synthesis: Concise Preparation of (+)-Conduritol F from Benzene

Abstract
A synthesis of the naturally occurring cyclohexenetetrol (+)-conduritol F [(+)-1], and its unnatural antipode (-)-1, has been developed in five steps from benzene using Pseudomonas putida oxidation to introduce the necessary cis-1,2-diol functionality.

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