Studies in latex agglutination: An approach to the determination of optimum conditions for discrimination between rheumatoids and normals

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Abstract
Optimum conditions for latex agglutination by rheumatoid factors have been investigated with respect to pH, ionic strength, gamma globulin concentration and heat of inactivation. A large number of sero‐negative cases of rheumatoid arthritis was studied. Best discrimination between rheumatoids and normals was found at pH 8.4 instead of at pH 8.2, with 0.6 per cent instead of 1.0 per cent sodium chloride, without gamma globulin and without heat except for 15 minutes inactivation at 56 C.