Effect of Influenza Virus Infection on the Pulmonary Retention of Inhaled 144Ce and Subsequent Survival of Mice

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Abstract
The effect of respiratory infection on the pulmonary retention of 144Ce and subsequent survival rates were studied in mice inoculated with influenza virus either at 1 week or at 3, 6 or 12 months after exposure by inhalation to 144CeO2. Infection of mice one week after exposure by inhalation to relatively insoluble 144CeO2 significantly increased the pulmonary retention of 144Ce. This resulted in an increased beta radiation dose to the lungs and a significant decrease in survival. Infection at 3, 6 or 12 months had no significant effect on 144Ce retention but significantly decreased survival. Mice were also exposed by inhalation to relative soluble 144CeCl, either one or two weeks after influenza virus inoculation while the viral pneumonitis was greatest. Infected mice deposited less 144Ce in their lungs and cleared it more rapidly from the lungs than noninfected mice during the first week after inhalation exposure. There was no effect on the long-term retention of 144Ce inhaled as 144CeCl3.

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