Pyridazines; XXX1,2. A Novel Approach to Pyrido[2,3-d] pyridazines by Annelation of the Pyridine Ring to the 1,2-Diazine System
- 1 January 1986
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1986 (10) , 862-864
- https://doi.org/10.1055/s-1986-31809
Abstract
Procedures for high-yield syntheses of 2-ethoxy- and 2-dimethylamino-4-arylpyrido [2,3-d]pyridazines (3a, b, 5), 3-alkyl- and 1-alkyl-4-aryl-1,2-dihydro-2-oxopyrido[2,3-d]pyridazines (4b, 6) as well as ethyl 4-aryl-1,2-dihydro-2-oxopyrido[2,3-d]pyridazine-3-carboxylates (7a, b) starting from 5-amino-4-pyridazinyl aryl ketones (1a, b) are reported. Considerable variability of the substitution pattern in the pyridine moiety of this bicyclic system is provided by the proposed strategy of annelation of the pyridine ring to a preformed pyridazine nucleus.Keywords
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