Bone-Marrow Transplantation in AIDS

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Abstract
To the Editor: The acquired immunodeficiency syndrome (AIDS) has a two-year mortality rate estimated to exceed 80 per cent, with no reported cases of spontaneous recovery of normal immunologic function once opportunistic infections have appeared.1 Our early experience2 with the unrelenting course of AIDS in patients, despite our aggressive and prompt use of antimicrobial agents and our preliminary attempts at therapy using alpha interferon, thymosin fraction 5, and transfer factor, which failed to yield any measurable alteration of immune function, led us to further attempts to restore immunocompetence in our patients. Because a profound, apparently broad-based, progressive immunodeficiency is present, . . .