Localization of neurotrophin receptors in olfactory epithelium and bulb

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Abstract
We used in situ hybridization to localize trk, trk B and trk C mRNA, in rat and cat olfactory bulb. Expression of mRNA encoding truncated trk B receptors was seen in all layers, while only very modest full-length trk B expression could be detected. trk C hybridization was seen in all layers, most dense in the mitral cell layer. The localization of full-lenght tyrosine kinase trk B receptor in olfactory bulb and epithelium was examined with immunohistochemistry. trk B-like immunoreactivity was seen in the fila olfactoria, epithelium and in vitro, in olfactory sensory neurones. Since BDNF is expressed by olfactory sensory neurone target cells in the olfactory bulb, these data suggest that BDNF may act as a target derived neurotrophic factor in the primary olfactory system.

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