Changes in Cell and Plasma Volumes Produced by Total Body X Radiation

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Abstract
The red cell volume was detd. by the introduction of p32-labeled homologous erythrocytes and the plasma volume with plasma tagged with I131 or with Evans blue soln. Following irradiation of rabbits by 1000 r of X-rays there is a large drop in erythrocyte volume as measured by p32_tagged cells beginning with the 3rd day and reaching a depth at about the 17th day after irradiation, followed by a slow recovery. There is at first a slight concomitant plasma-volume drop followed by a rise on about the 10th day that elevates the lowered total volume but does not bring it up to normal in 23 days. Similar changes occur in mice that have been exposed to 575 r.