Globin Insulin: Clinical Trial

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Abstract
Globin insulin was used in single daily doses in 36 cases of which 33 had had no previous treatment. All had a history of acute onset of diabetes. The diet was approx. the same for all patients. In 10 cases perfect control, both clinical and biochemical, was obtained. The avg. dose in this group was 20 units. In 16 cases control was only fair. Hyperglycemia and glycosuria persisted although weight and general health were maintained. Insulin reactions frequently occurred in this group even when the dose was increased only to control the symptoms while hyperglycemia persisted. Six of this group have been changed to protamine zinc insulin with satisfactory results. In ten cases, control was definitely inadequate and they were transferred to the protamine zinc insulin-regular insulin mixture. Globin insulin is considered to have a limited place in the treatment of mild and moderately severe diabetes.

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