Glutathione–insulin transhydrogenase activity in pregnant mouse mammary gland: hormonal influences studied in tissue culture

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Abstract
Glutathione-insulin transhydrogenase (GIT) [EC 1.8.4.2] activity has been shown to be stimulated in culture of explants of pregnant mouse mammary gland by a mixture of insulin, cortisol and prolactin. Since this hormone mixture stimulates lactogenesis in vitro, the increase in GIT activity may be functionally related to one of the processes of milk secretion or ejection. Oxytocin is degraded by GIT, and the interaction of this hormone with its mammary gland receptors may be influenced by the change in enzyme activity. The increase in GIT activity caused by insulin, cortisol and prolactin in vitro can be prevented by the addition of progesterone or oxytocin to the culture medium.

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