Sex Differences in Analgesia: A Randomized Trial of μ versus κ Opioid Agonists
- 1 January 2004
- journal article
- clinical trial
- Published by Southern Medical Association in Southern Medical Journal
- Vol. 97 (1) , 35-41
- https://doi.org/10.1097/01.smj.0000085743.68121.a9
Abstract
Objectives: We sought to evaluate whether there is a sex difference in the analgesic response to μ versus κ opioids in the management of acute moderate to severe pain of injury in the emergency department. Methods: The study was a randomized, double-blind, clinical trial comparing the prototypical μ-receptor agonist, morphine sulfate, to the prototypical κ agonist, butorphanol. The primary...Keywords
This publication has 21 references indexed in Scilit:
- Sex-related differences in mechanical nociception and antinociception produced by μ- and κ-opioid receptor agonists in ratsEuropean Journal of Pharmacology, 2002
- Sex differences in opioid antinociception: κ and ‘mixed action’ agonistsDrug and Alcohol Dependence, 2001
- Acute pain and pain control: State of the artAnnals of Emergency Medicine, 2000
- The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative painPain, 1999
- Kappa–opioids produce significantly greater analgesia in women than in menNature Medicine, 1996
- Gender difference in analgesic response to the kappa-opioid pentazocineNeuroscience Letters, 1996
- Multiple opioid systems and painPain, 1986
- Drug and Neurotransmitter Receptors in the BrainScience, 1984
- Multiple opiate receptors: Support for unique mu, delta and kappa sitesNeuropharmacology, 1982
- Opiate Receptors and Internal OpiatesScientific American, 1977