PENICILLAMINE IN ANKYLOSING-SPONDYLITIS - A DOUBLE-BLIND PLACEBO CONTROLLED TRIAL

  • 1 January 1985
    • journal article
    • research article
    • Vol. 12  (4) , 735-737
Abstract
A double blind placebo controlled trial was carried out over a 6-month period on 17 patients with ankylosing spondylitis (AS) to assess the effect of the second line antirheumatic drug, D-penicillamine. The patients included 13 with peripheral joint involvement. No significant improvement over placebo was detected in a variety of clinical and laboratory indices in the patients receiving active treatment. This controlled trial would not support a use for penicillamine in AS.