Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurones via a reflex centre in the brain stem
- 1 December 1983
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 324 (4) , 293-295
- https://doi.org/10.1007/bf00502626
Abstract
Injection of 0.03 μg capsaicin into one femoral artery elecited a fall in blood pressure in the rat. This effect was completely and reversibly abolished following intrathecal injection of 1 nmol of the specific substance P antagonist [D-Pro2,D-Trp7,9] substance P. The capsaicin-evoked depressor reflex is therefore exclusively mediated by substance P-containing primary afferent fibres. Using spinal rats or decerebration experiments, the centre of the capsaicin-evoked reflex fall in blood pressure could be localized in the brain stem.This publication has 21 references indexed in Scilit:
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