THE PATHOGENESIS OF HEMORRHAGE IN ARTIFICIALLY INDUCED FEVER

Abstract
In the present survey the influence of fever upon the circulating blood platelets, prothrombin and fibrinogen was studied in exptl. animals and in man. Total platelet counts, qualitative and quantitative studies of megakaryocytes in serial sternal marrow punctures, quantitative prothrombin and fibrinogen detns., with histopathologic studies of the liver were made. The hemorrhagic diathesis is directly proportional to the degree of damage occurring in one or both of these essential factors in the coagulation mechanism.