Affinity Chromatography Systems for Artificial Liver Support
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Biomaterials, Medical Devices, and Artificial Organs
- Vol. 5 (2) , 205-221
- https://doi.org/10.3109/10731197709118673
Abstract
The physical, adsorptive, and flow properties of two albumin conjugated agarose materials have been investigated in vitro to determine whether they could be used in artificial liver support systems to enhance the removal of toxic proteinbound substances. The results of binding of chenodeoxycholic acid and unconjugated bilirubin and flow experiments with blood and saline suggested that there could be advantages in using the SepharoseR rather than Bio-GelR albumin agarose in future haemoperfusion systems. However, further modifications are needed before the former can be successfully scaled up for human use.This publication has 10 references indexed in Scilit:
- Effects of haemoperfusion through charcoal or XAD-2 resin on an animal model of fulminant liver failureGut, 1974
- CHARCOAL HÆMOPERFUSION IN THE TREATMENT OF FULMINANT HEPATIC FAILUREThe Lancet, 1974
- Removing Substances from Blood by Affinity ChromatographyJournal of Clinical Investigation, 1974
- Removing Substances from Blood by Affinity ChromatographyJournal of Clinical Investigation, 1974
- Frequency and Type of Renal and Electrolyte Disorders in Fulminant Hepatic FailureBMJ, 1974
- Toward an Artificial LiverGastroenterology, 1974
- Red Blood Cell Damage by Shear StressBiophysical Journal, 1972
- PLASMA BILIRUBIN DETERMINATION IN THE NEWBORN INFANTPublished by American Academy of Pediatrics (AAP) ,1965
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- A Spectrophotometric Method for Quantitating Hemoglobin in Plasma or SerumAmerican Journal of Clinical Pathology, 1950