ATP Prevents both Hydroperoxide‐Induced Hydrolysis of Pyridine Nucleotides and Release of Calcium in Rat Liver Mitochondria

Publisher Website
Google Scholar
Abstract
The mechanism of the hydroperoxide-induced release of Ca from rat liver mitochondria was investigated. In Ca-loaded mitochondria, both the hydroperoxide-induced hydrolysis of pyridine nucleotides and the release of Ca is inhibited by intramitochondrial ATP. In submitochondrial particles in the absence of ATP, a hydrolytic product of NAD+, probably ADP-ribose, binds covalently to a protein of the inner mitochondrial membrane. A compound deriving from NAD(P)+ may be an important factor in the Ca release mechanism in rat liver mitochondria.