EFFECTS OF BENZODIAZEPINES ON BINDING OF TRYPTOPHAN IN SERUM - CONSEQUENCES ON 5-HYDROXYINDOLES CONCENTRATIONS IN RAT-BRAIN

  • 1 January 1975
    • journal article
    • research article
    • Vol. 1  (2) , 209-216
Abstract
Benzodiazepines (diazepam, oxazepam, chlordiazepoxide) inhibited competitively the binding of tryptophan onto rat serum albumin. In vivo treatment with 1 of these compounds (e.g., chlordiazepoxide) induced a significant increase in the concentration of free tryptophan in serum. The high levels of both 5-hydroxyindoles and tryptophan which occurred in the rat brain after any benzodiazepine administration could be at least partly the consequence of its effect on tryptophan binding in blood.

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