Narcolepsy and the HLA System
- 1 March 2001
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 344 (9) , 692
- https://doi.org/10.1056/nejm200103013440918
Abstract
In the second part of their review of the HLA system (Sept. 14 issue),1 Klein and Sato state that the HLA class II association in human narcolepsy is due to linkage disequilibrium with mutations in the gene coding for the hypocretin type 2 receptor (HCRTR2). HCRTR2 is located on human chromosome 6, but at a very large genetic distance from the HLA loci; there is no linkage disequilibrium between the HLA alleles and HCRTR2 over a distance of more than 30 million base pairs and 33.4 centimorgans. However, there is a different association between narcolepsy and the HLA system. Microsatellite-marker and sequencing studies of the HLA class II region have shown that HLA-DQ is the primary susceptibility locus for human narcolepsy in the HLA region.2-4Keywords
This publication has 4 references indexed in Scilit:
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- A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brainsNature Medicine, 2000
- HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy.Immunogenetics, 1997
- Extensive HLA class II studies in 58 non‐DRB1*15 (DR2) narcoleptic patients with cataplexyTissue Antigens, 1997