A Small Molecule Inhibits Akt through Direct Binding to Akt and Preventing Akt Membrane Translocation
Open Access
- 1 March 2010
- journal article
- research article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 285 (11) , 8383-8394
- https://doi.org/10.1074/jbc.m109.094060
Abstract
No abstract availableKeywords
This publication has 51 references indexed in Scilit:
- Large-scale Proteomics Analysis of the Human KinomeMolecular & Cellular Proteomics, 2009
- A complex interplay between Akt, TSC2 and the two mTOR complexesBiochemical Society Transactions, 2009
- Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitorsNature Biotechnology, 2007
- A transforming mutation in the pleckstrin homology domain of AKT1 in cancerNature, 2007
- Perturbations of the AKT signaling pathway in human cancerOncogene, 2005
- Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR ComplexScience, 2005
- Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)Oncogene, 2002
- Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTENCell, 1998
- PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate CancerScience, 1997
- Molecular Cloning and Characterization of a New Member of the RAC Protein Kinase Family: Association of the Pleckstrin Homology Domain of 3 Types of RAC Protein Kinase with Protein Kinase C Subspecies and βγ Subunits of G ProteinsBiochemical and Biophysical Research Communications, 1995