QUANTITATIVE ESTIMATION OF ADRENOCORTICAL HORMONES AND THEIR α-KETOLIC METABOLITES IN URINE

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Abstract
Urinary corticosteroid patterns were estimated before and after adrenocortical stimulation by exogenous corticotrophin (ACTH). The results indicate that changes in corticosteroid biosynthesis and metabolism depend on the duration of stimulation. Immediate effects are an increase in corticosterone production above that of cortisol in favor of all 11-hydroxycompounds. Late effects are characteristic of the patterns in Cushing''s disease including a high F/B ratio and low values for the 11-hydroxy-allocompounds (allotetrahydrocortisol and allotetrahydrocorticosterone). Changes in the ratios between cortisol, corticosterone and Reichstein''s S as observed in Cushing''s disease, adrenogenital syndrome and Addison''s disease can be imitated by ACTH-induced acceleration of corticosteroid biosynthesis.