Ultrastructure of the bone marrow in three murine strains with non-malignant lymphoproliferative syndromes NZBxW, BXSB, and MRL/1pr

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Abstract
Three mouse strains, NZBxW, BXSB, and MRL/1pr have well documented congenital lymphoproliferative syndromes and lupus-like disease. We studied the ultrastructures of the marrows of these mice searching for a model for intramedullary lymphopoiesis. In MRL/1pr, the strain with the most severe disease, the marrow was largely populated by large lymphocytes associated with dark branching stromal cells. These stromal cells are apparently of a recently recognized cell type which has been associated with extremely accelerated eosinophilopoiesis and erythropoiesis. They did not appear in the lymph nodes and spleens of the MRL/1pr mice or in the marrows of the other strains. BXSB marrows showed some non-proliferant lymphocytic infiltrates and heightened erythropoiesis while NZBxW marrows resembled controls. We suggest that the dark stromal cells in the MRL/1pr marrows were important in supporting the production or differentiation of lymphoid precursor cells.