Influence of Hydrocortisone Acetate on the Chemical Composition of Experimental Granulomas.

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Abstract
Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 [mu]g) impregnation significantly inhibited granuloma growth for approximately 5 days. Steroid treatment significantly reduced the total amount and concentration of collagen, total protein, DNA and RNA. Water content was increased by about 4% in the steroid treatment granulomas. Hydrocortisone acetate (300 [mu]g) impregnation resulted in significant reduction of both total Cl4-L-proline incorporation and specific activity (cpm/[mu]g protein), measured at 12 and 24 hours after implantation.