Gene Encoding the β Subunit of S100 Protein Is on Chromosome 21: Implications for Down Syndrome
- 11 March 1988
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 239 (4845) , 1311-1313
- https://doi.org/10.1126/science.2964086
Abstract
S100 protein is a calcium-binding protein found predominantly in the vertebrate nervous system. Genomic and complementary DNA probes were used in conjunction with a panel of rodent-human somatic cell hybrids to assign the gene for the beta subunit of S100 protein to the distal half of the long arm of human chromosome 21. This gene was identified as a candidate sequence which, when expressed in the trisomic state, may underlie the neurologic disturbances in Down syndrome.Keywords
This publication has 27 references indexed in Scilit:
- Free proximal trisomy 21 without the Down syndromeClinical Genetics, 1987
- The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid β-protein geneNature, 1987
- Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European familiesNature, 1987
- Neuroendocrine Response to Estrogen and Sexual OrientationScience, 1985
- S100ao (αα) protein is mainly located in the heart and striated musclesBiochimica et Biophysica Acta (BBA) - General Subjects, 1985
- Calcium-sensitivity of brain microtubule proteins in the presence of S-100 proteinsCell Calcium, 1985
- Comparative Gene Mapping of Human Chromosome 21 and Mouse Chromosome 16aAnnals of the New York Academy of Sciences, 1985
- Modulation of brain protein phosphorylation by the S-100 proteinBiochemical and Biophysical Research Communications, 1982
- Effect of calcium ion on S-100, a protein of the nervous systemBiochemistry, 1969
- A soluble protein characteristic of the nervous systemBiochemical and Biophysical Research Communications, 1965