Determination of Paracetamol by a Flow Injection-Spectrophotometric Method
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 19 (19-20) , 2023-2038
- https://doi.org/10.1080/00032718608064544
Abstract
A flow injection-spectrophotometric determination of paracetamol is reported. The procedure is based on the oxidation of the analyte with potassium hexacyanoferrate (III) and reaction of the N-(hydroxyphenyl)-p-benzoquinonimine produced with phenol; both reactions are carried out at 80 × 1°C and in aqueous ammoniacal solution. Concentrations of paracetamol in 0.25-30 ppm range are determined; relative standard deviations are 0.4% (n=40).Injection rate 26 samples/h.The influence of foreign species and the determination of paracetamol in several pharmaceutical formulations are also reported.Keywords
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