SELECTIVE ANTIBACTERIAL ACTIVITY OF ACONITIC ACID

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Abstract
The ability of aconitic, glycolic, butyric, propionic, and oxalic acids to inhibit selectively a strain of Pseudomonas aeruginosa in the presence of Staphylococcus aureus was studied. Aconitic acid, at levels of one and 2 mg/ml of trypticase soy broth, inhibited P. aeruginosa but not S. aureus. Both organisms were completely inhibited by aconitic acid in a concentration of 5 mg/ml. Aconitic acid also produced an antibacterial effect when added to trypticase soy agar at a level of 2 mg/ml. Freshly isolated strains of P. aeruginosa failed to grow in the latter substrate whereas newly isolated strains of S. aureus were not inhibited. Of the remainder of the acids studied, only glycolic acid produced significant selective inhibition of P. aeruginosa in the presence of S. aureus.

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