Stereoselective synthesis of crinosterol [(22E,24S)-ergosta-5,22-dien-3β-ol]

Abstract
A stereoselective synthesis of crinosterol, (22E,24S)-ergosta-5,22-dien-3β-ol, was developed from (20S)-6β-acetoxy-3α,5-cycle-5α-pregnane-20-carbaldehyde using the Claisen rearrangement of an appropriate precursor of established absolute configuration.