ZINC-METABOLISM IN UREMIA

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 94  (5) , 693-698
Abstract
Subnormal plasma Zn levels have been reported in uremic patients. Detailed studies regarding Zn status in uremia are not available. Patients [25] with chronic renal failure (10 undergoing maintenance hemodialysis, 5 receiving chronic peritoneal dialysis and 10 nondialyzed azotemic patients) had lower concentration of Zn in plasma, leukocytes, and hair as well as increased plasma ammonia and RNase activity compared to age- and sex-matched controls (P < 0.001). Similar biochemical changes were reported in experimentally induced Zn deficiency in both animals and man, except that erythrocyte Zn concentration was elevated in these patients. High erythrocyte Zn concentration may be related to ineffective erythropoiesis in uremia. Abnormality in Zn metabolism occurs commonly in patients with chronic renal failure and it develops prior to initiation of dialysis treatment.

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