Effect of Intravenous and Intraduodenal Administration of Escherichia Coli Endotoxin on the Porcine Pancreas as Evaluated by Changes in the Serum Cationic Trypsin-Like Immunoreactivity

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Abstract
In six pigs intravenous administration of Escherichia coli endotoxin caused septic shock and a significant increase in serum cationic trypsin-like immunoreactivity (CTLI), with activation of cationic trypsinogen to trypsin and formation of complexes between cationic trypsin, on the one hand, and alpha2-macroglobulin and alpha,-antitrypsin, on the other, compatible with acute pancreatitis. In contrast, intraduodenal infusion of E.coli endotoxin to seven other pigs was without effect on the general circulation and on the serum CTLI.

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