Clinical evaluation of the Chinese herbal medicine formula STA‐1 in the treatment of allergic asthma

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Abstract
Although some formulae of traditional Chinese medicines (TCM) have been used for antiasthma treatment, few of them have had sufficient discussion on their efficacy, safety and mechanisms. In this study, the availability of the TCM formula STA‐1 for the treatment of allergic asthma was investigated by conducting a double‐blind, placebo‐controlled and randomized trial. One hundred and twenty patients between the ages of 5 to 20 years with mild‐to‐moderate asthma were included. These patients were treated with either STA‐1 or placebo in a dose of 80 g/kg/day and were administered twice daily for 6 months. The main outcome measures were a daily diary record of symptoms, supplementary bronchodilator and glucocorticoid treatment, changes of pulmonary function (forced expiratory volume in 1 s), changes of total and Dermatophagoides pteronyssinus (DP)‐specific IgE and side effects. The results showed a statistically significant reduction of symptom scores, systemic steroid dose, total IgE and specific IgE in the STA‐1 group. Furthermore, STA‐1 also improved the pulmonary lung function FEV1 compared with the placebo group and only minimal side effects were shown. These results suggested that STA‐1 is available for the treatment of mild‐to‐moderate chronic asthma. Copyright © 2006 John Wiley & Sons, Ltd.