Comparison of 17-Ketosteroid and Uropepsin Data on 69 Healthy Adult Males.

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Abstract
Uropepsin and 17-ketosteroid excretion values were detd. on the same urines for a group of healthy adult males. The group was divided according to age; 17-30 yrs., 31-40 yrs., 41-58 yrs. Results: 24-hr. uropepsin and 17-KS; 17-30 yr. group[long dash]low positive correlation; 41-58 yr. group[long dash]higher negative correlation. Day to night ratios of uropepsin and 17-KS; 17-30 yr. and 31-40 yr. groups[long dash]high positive correlation. Other values were insignificant. Since 17-KS excretion is believed to reflect adrenal cortical activity, the findings point to the possibility that the adrenal cortex exerts a controlling effect on uropepsin excretion in young men. The significant negative correlations obtained for the 24-hr. excretion for the older men coupled with decline in 17-KS with age may mean that the decreasing activity of the adrenal cortex is less effective in influencing uropepsin secretion and some other influence has become more effective. Or a decline may occur in the secretion of the adrenal cortical 17-KS precursors without a decline in the adrenal cortical factor affecting gastric secretory activity.