Alpha 1(IV) and alpha 2(IV) collagen genes are regulated by a bidirectional promoter and a shared enhancer.
- 1 December 1988
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 85 (24) , 9679-9682
- https://doi.org/10.1073/pnas.85.24.9679
Abstract
Collagen IV is the major structural component of basement membranes and is a heterotrimer composed of two .alpha.1(IV) and one .alpha.2(IV) chains. Most collagen genes are dispersed in the human genome, such as the genes for collagen I, which are located on chromosomes 7 [.alpha.1(I)] and 17 [.alpha.2(I)]. In contrast, we have found that the murine .alpha.1(IV) and .alpha.2(IV) collagen chain genes exist in a head-to-head arrangement on opposite strands separated by 130 base pairs. By transfecting various portions of these genes into cells, we have found that transcription of the .alpha.1(IV) and .alpha.2(IV) genes is regulated by a bidirectional promoter located between the two genes working in concert with an enhancer located in the first intron of the .alpha.1(IV) chain gene.This publication has 24 references indexed in Scilit:
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