A putative novel alpha/beta hydrolase ORFan family in Bacillus
- 4 May 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (14) , 3175-3182
- https://doi.org/10.1016/j.febslet.2005.04.030
Abstract
A large number of sequences in each newly sequenced genome correspond to lineage and species-specific proteins, also known as ORFans. Amongst these ORFans, a large number are sequences with unknown structures and functions. We have identified a family of sequences, annotated as hypothetical proteins, which are specific to Bacillus and have carried out a computational study aimed at characterizing this family. Fold-recognition methods predict that these sequences belong to the α/β hydrolase fold. We suggest possible catalytic triads for the ORFans and propose a hypothesis regarding the possible families within the α/β hydrolase superfamily to which they may belongKeywords
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