ANNULATE LAMELLAE IN HUMAN MALIGNANT-TUMORS - REPORT OF 3 CASES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 102  (8) , 426-430
Abstract
During the course of applying EM to diagnostic surgical pathological specimens, 3 malignant tumors (malignant melanoma, fibrous mesothelioma, lymphoblastic lymphoma) contained annulate lamellae, distinctive intracytoplasmic organelles composed of membrane stacks interrupted by constrictions or pores. In 1 case annuli and lamellae were present, a combination rarely described in human tissue and animal models. In this material, the annuli of the annulate lamellae were structurally similar to nuclear pores. The abundant fibrils are probably related to the unusual configuration of the annulate lamellae. A morphologic relationship of the annulate lamellae to the endoplasmic reticulum (cases 1 and 2) and nuclear membrane (case 3) supports the theory that annulate lamellae may be related to both structures.

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