The Relation between Experimental Liver Carcinoma and Liver Cirrhosis Induced by Simultaneous Administration of p-Dimethylaminoazobenzene and Carbon Tetrachloride

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Abstract
The effect of simultaneous administration of p-dimethylaminoazobenzene (DAB) and carbon tetrachloride (CC14) was experimentally studied on rats. The morphological changes in the early stage of simultaneous administration of D A B and CC14 were characterized by an earlier appearance of cholangiofibrosis or of liver cirrhosis than in those produced by DAB or CC14 alone. Simultaneous administration of both agents invariably resulted in statistically significant higher incidences of liver carcinoma, liver cirrhosis, liver carcinoma with liver cirrhosis, and nodular hyperplasia than the administration of DAB alone. There was no histological difference between the liver carcinomas caused by combined use of DAB and CC14 and those by the administration of D A B alone. CC14 caused a decrease in protein-bound azo-dye in the liver in the course of carcinogenesis by DAB. The mechanism of the activity of CCl4 in the development of D AB-induced liver carcinoma was discussed on the basis of the relation between the incidence of liver carcinoma and the amount of protein-bound azo-dye in the liver.