Microwave Radiation (2450-MHz) Potentiates the Lethal Effect of Endotoxin in Mice

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Abstract
Groups of male CBA/J mice were injected with Salmonella typhimurium lipopolysaccharide (LPS) and irradiated with 2450 MHz (CW) microwaves. The LD50 of LPS was determined for mice irradiated at 30, 20, 10 and 5 mW/cm2 immediately following injection. The average specific absorption rate was .apprx. 0.6 W/kg per 1 mW per cm2 incident power. An equal number of animals served as sham-irradiated controls for each power density. The mice were placed individually in small containers and were maintained at 22.degree. C and 50% relative humidity for 2 h. Following irradiation the mice were returned to their home cages and were observed for 48 h. A significant decrease in the LPS dose required for LD50 of the mice was observed at power densities of 20 and 30 mW/cm2. High ambient temperature (30.degree. C) also potentiated the lethal effect of endotoxin. Microwave irradation prior to LPS injection did not affect the lethal action of LPS.