Synthesis of 4-(Trifluoromethylpyridyl)phenol Derivatives
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (12) , 923-924
- https://doi.org/10.1055/s-1991-20925
Abstract
2,6-Di-tert-butyl-4-(trifluoromethylpyridyl)phenols are electrosynthesized via SRN1 reaction of chloro(trifluoromethyl)-pyridines with 2,6-di-tert-butylphenoxide. The tert-butyl groups are then eliminated by a transalkylation reaction, using trifluoromethanesulfonic acid and toluene.Keywords
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