VASOCONSTRICTOR RESPONSES INDUCED BY α‐ADRENORECEPTOR AGONISTS BEFORE AND AFTER REMOVAL OF THE ENDOTHELIAL CELLS OF DOG MESENTERIC ARTERIES

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Abstract
The stainless cannula inserting method was used to investigate the effects of .alpha.-adrenoreceptor agonists (phenylephrine, .alpha.1-agonist and xylazine, .alpha.2-agonist) and calcium chloride on isolated and perfused dog mesenteric arteries with and without saponin treatment. By intraluminal administration, phenylephrine and calcium chloride caused vasoconstriction in a dose-related manner while xylazine was without significant effect. After intraluminal treatment with 3 mg of saponin, the endothelia of the arteries were completely removed as confirmed by pathological examinations. Phenylephrine- and xylazine-induced responses were not influenced by saponin treatment whereas calcium chloride-induced constriction was significantly enhanced.