RATIONAL BROMIDE TREATMENT

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Abstract
Bromide treatment to be rational must, on the one hand, produce the desired effect of the drug and, on the other hand, avoid the danger of bromide intoxication. The foundations of bromide action, and consequently also those of a rational treatment, are based on the relations between chlorides and bromides—the chloride-bromide equilibrium or replacement—which therefore has to be discussed briefly. Sodium chloride constitutes the greater part of the electrolytes of the body, and its ions are essential for the function of most cells. Since it is constantly excreted, mainly in the urine, it must be constantly replenished. The body maintains its chloride concentration with remarkable constancy. The excretion varies with the salt intake but lags somewhat behind in time. According to Borelli and Girardi,1with a steady income, equilibrium is reached within three or four days. If the supply of salt is stopped, excretion falls within three days to

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