Cardiovascular response to treadmill exercise in untrained rats

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Abstract
O2 consumption (.ovrhdot.VO2), cardiac output (.ovrhdot.Q), heart rate (HR), stroke volume (SV) and O2 extraction from blood (CaO2[arterial O2 content]-C.hivin.VO2[mixed venous O2 content]) were measured in untrained rats, at rest and during treadmill running at various speeds (10-41 m/min). .ovrhdot.VO2 increased linearly as a function of running speed and maximal values (83 ml O2 .cntdot. kg-1 .cntdot. min-1) represented a 5-fold increase over resting values. .ovrhdot.Q, HR, SV and CaO2-C.hivin.VO2 increased linearly as functions of .ovrhdot.VO2. C.hivin.VO2 decreased with increasing .ovrhdot.VO2; CaO2 remained independent of .ovrhdot.VO2, averaging 19 vol%. Maximal values of these variables and their relationship to .ovrhdot.VO2 were as follows: .ovrhdot.Q = 4.3 .ovrhdot.VO2 + 184; .ovrhdot.Qmax [maximum] = 543 ml .cntdot. kg-1 .cntdot. min-1; HR = 3.02 .ovrhdot.VO2 + 340; HRmax = 595 beats .cntdot. min-1; SV = 0.004 .ovrhdot.VO2 + 0.603; SVmax = 0.92 ml .cntdot. kg-1 .cntdot. beat-1; CaO2-C.hivin.VO2 = 0.13 .ovrhdot.VO2 + 5.62; CaO2-C.hivin.VO2 max = 15.5 vol%; C.hivin.VO2 = -0.12 .ovrhdot.VO2 + 12.94; C.hivin.VO2 min [minimum] = 3.4 vol%. Apparently HR, SV and CaO2-C.hivin.VO2 make significant contributions to the augmentation of .ovrhdot.VO2 in the exercising rat.

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