Leukemia inhibitory factor, leukemia inhibitory factor receptor, and glycoprotein 130 in rhesus monkey uterus during menstrual cycle and early pregnancy.
Open Access
- 1 August 2000
- journal article
- Published by Oxford University Press (OUP) in Biology of Reproduction
- Vol. 63 (2) , 508-512
- https://doi.org/10.1095/biolreprod63.2.508
Abstract
This goal of this study was to examine immunohistochemical distribution of leukemia inhibitory factor (LIF), LIF receptor (LIFR), and glycoprotein (gp) 130 in rhesus monkey uterus during the menstrual cycle and early pregnancy. Pregnancy rate was significantly reduced in the control group from 66.7% (12 of 18) to 22.2% (4 of 18) with an injection of goat anti-human recombinant LIF immunoglobulin G into the uterine lumen on Day 8 of pregnancy. LIF was mainly localized in glandular and luminal epithelium. LIF immunostaining during the luteal phase was stronger than it was during the proliferative phase. LIF staining gradually increased from Day 3 of pregnancy and reached its highest level on Day 9. LIFR was mainly localized in the glandular and luminal epithelium. LIFR staining during the luteal phase was stronger than it was during the proliferative phase. LIFR staining began to increase from Day 3 of pregnancy and reached a high level on Days 9 and 11. Gp130, a signal-transducing receptor component of LIF, was mainly localized in the glandular epithelium. A high level of gp130 was found on Days 16 and 20 of menstrual cycle, and from Days 5 to 11 of pregnancy. These results suggest that LIF may play an important role in monkey implantation, as it does in mice.Keywords
This publication has 20 references indexed in Scilit:
- Review: The role of leukaemia inhibitory factor in the establishment of pregnancyJournal of Endocrinology, 1999
- Leukaemia inhibitory factor in human endometrium throughout the menstrual cycleJournal of Endocrinology, 1996
- Leukemia inhibitory factor, LIF receptor, and gp130 in the mouse uterus during early pregnancyMolecular Reproduction and Development, 1995
- Leukaemia inhibitory factor and the regulation of pre-implantation development of the mammalian embryoMolecular Reproduction and Development, 1994
- Expression of Leukemia Inhibitory Factor in Human Endometrium and Placenta1Biology of Reproduction, 1994
- LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF ReceptorScience, 1993
- The Leukemia Inhibitory Factor and Its ReceptorPublished by Elsevier ,1993
- Blastocyst implantation depends on maternal expression of leukaemia inhibitory factorNature, 1992
- The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF ReceptorScience, 1992
- Distribution and comparison of receptors for leukemia inhibitory factor on murine hemopoietic and hepatic cellsJournal of Cellular Physiology, 1991