Association of British Neurologists Autumn Meeting, Newcastle University meeting at Durham, 12-14 September 2001

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Abstract
The aim of this study is to address whether neuropsychological measures or imaging scores best predict which patients with questionable dementia progress to fulfil criteria for Alzheimer's disease (AD). MRI images of 50 subjects (18 with early AD, mean MMSE 21.4, and 32 with memory complaints, mean MMSE 27.3) were examined using the temporal lobe rating scale. Subjects underwent a standard battery of neuropsychological tests at baseline, and were clinically followed up for a mean of 19 months. Patients who converted to AD (converters n=11), relative to non-converters, were impaired at baseline assessment on general cognitive tests (Addenbrookes cognitive examination (ACE) and ADAS cog), measures of episodic memory, category fluency, and the graded naming test. The mean scores of the temporal lobe rating scale demonstrated that converters had more hippocampal and parahippocampal atrophy than non-converters. Discriminant analysis demonstrated that the best test for distinguishing the converters from the questionable group, was the ACE score. In combination, the medial temporal lobe rating and graded naming test were also contributory.

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