Multiple Ca2+ signaling pathways converge on CaM kinase in PC12 cells
- 15 June 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 304 (2-3) , 237-240
- https://doi.org/10.1016/0014-5793(92)80627-s
Abstract
The role of multifunctional Ca2+/calmodulin-dependent protein kinase (CaM kinase) in mediating various Ca2+ signaling pathways was examined in PC12 cells. Conversion of the kinase to a Ca2+-independent form was used to monitor which neurotransmitters activate the enzyme in situ. CaM kinase responds to Ca2+ influx elicited by ligand-gated Ca2+ channels for ATP and acetylcholine. It also responds to Ca2+ mobilization ofIP3-sensitive stores elicited by phospholipase C-linked receptors for ATP and acetylcholine as well as by caffeine. CaM kinase mediates the actions of many neurotransmitters and Ca2+ signaling pathways.Keywords
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