Influence of hyperthyroidism on the uptake and binding of calcium by cardiac microsomal fractions and on mitochondrial structure

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Abstract
Microsomes prepared from heart muscle of hyperthyroid dogs accumulate and exchange calcium more readily than do microsomes isolated from euthyroid heart muscle. The activity of the calcium-activated ATPase enzyme and cardiac stores of high energy phosphates and catecholamines are not influenced by the hyperthyroid state. Electron micrographs prepared from perfusion-fixed heart muscle failed to show evidence of an altered mitochondrial morphology associated with the hyperthyroid state.