COMPARATIVE EFFECT OF A SINGLE OR CONTINUOUS ADMINISTRATION OF SACCHAROMYCES BOULARDII ON THE ESTABLISHMENT OF VARIOUS STRAINS OF CANDIDA IN THE DIGESTIVE-TRACT OF GNOTOBIOTIC MICE

Google Scholar
  • 1 January 1982
    • journal article
    • research article
    • Vol. B133  (3) , 491-501
Abstract
S. boulardii became established in the digestive tract of monoxenic mice; the number of viable cells was .apprx. 107.5/g feces. This yeast was drastically eliminated from the digestive tract of gnotoxenic mice harboring a complex flora of human origin. In monoxenic mice harboring S. boulardii, C. albicans became established at a level equivalent to that observed in monoxenic mice harboring C. albicans alone. If gnotoxenic mice receive a concentrated suspension of viable S. boulardii cells so as to steadily maintain a population level close to 109 viable cells, C. albicans then becomes established at a level 10-50 times lower than that reached by the yeast strain alone. The antagonistic effect exerted in vivo by S. boulardii was preventive and curative. It was active against C. albicans, C. krusei and C. pseudotropicalis strains, but ineffective against C. tropicalis. This antagonistic effect disappeared when S. boulardii cells were killed by heating.