MICRO-CIRCULATION OF INTESTINAL LYMPHOID FOLLICLES IN RAT PEYERS PATCHES
- 1 January 1981
- journal article
- research article
- Vol. 81 (3) , 481-491
Abstract
Peyer''s patch microvasculature carries recirculating lymphoid cells into lymphoid follicles and supports vigorous metabolic demands of crypts and replicating germinal centers. Scanning electron microscopy of methyl methacrylate casts of blood vessels in rat intestinal Peyer''s patches revealed that ascending arterioles pierce follicles and feed a subepithelial capillary network beneath the follicle surface. These capillaries interconnect with baskets of capillaries beneath adjacent crypts and flow into postcapillary venules in thymus-dependent areas around the follicle perimeters. This pattern is a modification of the fountain pattern in villi and reflects the secondary development of germinal centers of B lymphocytes between central ascending arterioles and peripheral postcapillary venules. Sections of glycol methacrylate-embedded follicles injected with India ink revealed multiple fine capillaries in germinal centers not detected by previous techniques. Capillary flow from follicle apex to adjacent crypts provides a route for feedback control of replenishment of the specialized antigen-trapping epithelium covering follicles, and it is an opportunity for absorbed materials and cellular products beneath the epithelium to modify migration of lymphocytes out of postcapillary venules into follicles.This publication has 8 references indexed in Scilit:
- Three-dimensional organization of the hepatic microcirculation in the rodent as observed by scanning electron microscopy of corrosion castsGastroenterology, 1980
- MICROCIRCULATION OF THE PANCREAS WITH SPECIAL REFERENCE TO PERIDUCTULAR CIRCULATION. A SCANNING ELECTRON MICROSCOPE STUDY OF VASCULAR CASTS Biomedical Research, 1980
- The endothelial structure of the postcapillary venules of the lymph node and the passage of lymphocytes across the venule wallJournal of Ultrastructure Research, 1979
- Sequential Uptake of Horseradish Peroxidase by Lymphoid Follicle Epithelium of Peyer's Patches in the Normal Unobstructed Mouse Intestine: An Ultrastructural StudyGastroenterology, 1977
- A Qualitative and Quantitative Morphologic Study of Peyer's Patches of the MouseArchivum histologicum japonicum, 1977
- Open Circulation in the Human Spleen. Dissection Scanning Electron Microscopy of Conductive-Stained Tissue and Observation of Resin Vascular CastsArchivum histologicum japonicum, 1977
- Microcirculation of the Rat Small Intestine as Studied by the Injection Replica Scanning Electron Microscope MethodArchivum histologicum japonicum, 1976
- Blood and lymph vessels in the jejunal villi of the white ratThe Anatomical Record, 1966