Studies on the Effect of Sodium Bisulfite on the Stability of Vitamin E

Abstract
Evidence has been obtained in studies with chicks that the inclusion of sodium bisulfite in a purified diet containing iron, manganese and copper salts accelerates the development of oxidative rancidity in unsaturated fat and increases the incidence and severity of vitamin E deficiency. Both encephalomalacia and exudative diathesis were observed. Encephalomalacia appeared to be the more acute form and exudative diathesis the more chronic form of vitamin E deficiency. The results showed, in agreement with evidence reported by other workers, that actively developing oxidative rancidity in unsaturated fat is directly concerned in the destruction of vitamin E and indicated that one of the functions of the vitaman is the maintenance of the integrity of unsaturated fatty acid molecules.