Effect of flecainide on cardiac output

Publisher Website
Google Scholar
Abstract
The effects of i.v. flecainide (2 mg/kg) on cardiac output was evaluated by a dye dilution method in 6 healthy nonsmokers. The study was of a double-blind, crossover, placebo-controlled, randomized and balanced design. Cardiac output, heart rate and stroke volume were measured 0, 10, 30, 60, 90, 120, 150, 180 and 240 min after the beginning of the flecainide infusion. Flecainide reduced cardiac output and stroke volume during the first 90 min and heart rate increased during the first 30 min after flecainide. Visual analog scales for alertness and dry mouth were determined 0, 10, 60 and 240 min after dosing. Alertness was reduced 60 min after flecainide, but there was no increase in dryness of the mouth.