A COMPARISON OF THE BRONCHOCONSTRICTOR AND β‐ADRENOCEPTOR BLOCKING ACTIVITY OF PROPRANOLOL AND ACEBUTOLOL

Publisher Website
Google Scholar
Abstract
The bronchoconstrictor and β‐adrenoceptor blocking activity of (±)‐propranolol, acebutolol and two of its analogues were compared in a group of littermate rats. Whilst the analogues of acebutolol had similar bronchoconstrictor potency to propranolol, acebutolol had considerably less activity. No correlation could be found between the degree of bronchoconstriction produced by the four drugs and their β‐adrenoceptor blocking activity in the airway smooth muscle. Acebutolol and its analogues show a wide variation in lipid solubility and membrane stabilizing actions but neither of these properties could be related to the production of bronchospasm.